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As we age, the body makes less, creating a much more difficult time replacing Glutathione as it gets used for immune responses, external oxidative stress, and mitigation of toxins in the body

In addition to cosmetic goals, wellness-focused patients, anti-aging candidates, and individuals seeking detox support may also benefit from glutathione therapy

A 2023 clinical trial demonstrated this relationship: high-dose nicotinamide riboside supplementation at 3,000 mg daily increased blood NAD+ levels five-fold while maintaining stable glutathione and GSSG levels [12]

To characterize compound engagement of TGR in adult worms ex vivo, the GSH/GSSG ratio was measured for compounds in Table 1