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The development of targeted nanomedicine approaches that modulate the immune response or control inflammation and damage directly within the kidney has the potential to eliminate the need for systemically acting drugs

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A fall, direct blow, or sudden strain may inflame or rupture the bursa

AnkB-deficient animals have sinus bradycardia, a prolonged QT interval, and other myocardial electrical phenotype changes, promoting myocardial mechanical remodelling as well as premature death, which is related to the low expression of -catenin in the intercalated disc and high expression in the cytoplasm caused by the loss of AnkB