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Given this, interest has grown in classifying and defining IC/BPS based on the presence or absence of these lesions, sometimes called Hunner lesion disease versus nonHunner lesion disease, or ulcerative IC and nonulcerative IC (Whitmore et al.)

Many patients report significant pain reduction within weeks, often experiencing continued improvement as new tissue develops

This review synthesizes current knowledge on HT's epidemiology, pathogenesis, and recent therapeutic advances, highlighting the complex interplay of genetic, environmental, and immunological factors that contribute to the disease's progression and management

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