Individuals uncomfortable with large capsules
This cardiac stress is one of the main reasons the drug is still in testing
Shastri A, Chakraborty S, Morganti C, Zaldana K, Rivera-Pea B, Zhang H, Verma D, Gitego N, Ma F, Aluri S, Pradhan K, Gordon-Mitchell S, Mantzaris I, Goldfinger M, FELDMAN EJ, Gritsman K, Shi Y, Hubner S, Yihua Q, Brown B, Khasawneh A, Skwarska A, Verma A, Konopleva M, Tabe Y, Gavathiotis E, Colla S, Gollob J, Dey J, Kornblau S , Koralov S, Ito K
In the glutaminolysis-fueled cytoplasmic NADPH-generating pathway (Figure 2E), there are 4 major mechanisms available to restore the mitochondrial matrix NADPH oxidized by IDH2