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miR-34a has been identified as a potential regulatory factor in NAFLD/MAFLD [59], and its association with ADAR2 is defined as a negative regulatory relationship: in HepG2 cells, ADAR2 overexpression downregulates miR-34a, while ADAR2 knockdown upregulates it

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Activation and cross-talk of cellular receptors and consequent activation of different signaling pathways contribute to limited activity of blockade of a single pathway