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The close link between smoking and the development of cardiovascular disease is particularly well-established, with several studies showing that the risk of myocardial infarction is overall 2-3 times higher in smokers than in non-smokers, and even much higher in heavy smokers (one pack or more per day) (Figure 2)

The health consequences of involuntary exposure to tobacco smoke: a report of the Surgeon General.: U.S

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