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Although the serum glycerol levels were similarly increased in WT/HFD mice and Insr P1195L/ +/HFD mice, the blood glucose levels after CL316432 administration were significantly higher in Insr P1195L/ +/HFD mice, indicating that enhanced lipolysis exacerbates hyperglycemia in Insr P1195L/ +/HFD mice

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We evaluate at the end of each cycle before deciding whether to repeat, adjust the dose, add a stack partner like TB-500, or transition to a maintenance approach

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