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This functional dichotomy includes the expression of specific markers, a particular cytokine pattern, and different types of energy metabolism ( Although the interior of a macrophage constitutes a hostile environment for any microbe or parasite, Leishmania adeptly manipulates host cell signaling, metabolism, and immune functions steering the macrophage toward an anti-inflammatory phenotype similar to M2 ( Leishmania unveils a dynamic relationship critical for determining the course of infection