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The pentose phosphate pathway is sometimes described as a shunt, rather than a pathway, because when pentoses are not needed for biosynthetic reactions, the pentose phosphate intermediates are recycled back into the mainstream of glycolysis by conversion into Fru-6-P and glyceraldehyde-3-phosphate

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10 Metabolite profiling The Expanded Newborn Screening Pilot Programme using liquid chromatographytandem mass spectrometry (LC-MS/MS) has been operating in three provinces of Tuscany since January 2002