found that phosphoglycerate mutase (Pgam) 5 is also involved in cell senescence, which is verified to stimulate mitochondrial fission
We showed that GDH1 knockdown significantly reduces intracellular -KG abundance in several liver and lung cancer cell lines and GDH1 knockdown also reduces -KG levels in certain breast cancer cells (MDA-MB231), HEL and K562 leukemia cells and brain tumor cells 19,21
GO analysis showed that EGCG affected genes involved in inflammation (regulation of MAPK cascade, neutrophil migration, transforming growth factor beta receptor binding, CD4-positive CD25-positive alpha-beta regulatory T cell differentiation, etc.), metabolism (response to lipid, glycosphingolipid metabolic process, lipid storage, etc.), and fibrosis (collagen receptor activity, etc.) (Figures 7F,H)
10.1093/carcin/bgv096 50 XinJ.JiangX.BenS.YuanQ.SuL.ZhangZ.et al (2022)