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It has been suggested that a discrepancy between the biological and chronological age of the endometrium (i.e., premature aging of the endometrium) in young women may account for some cases of endometrial factor infertility

We are currently exploring cationic or neutral water solubilizing groups to replace the carboxylic acids in RT to achieve higher temporal resolution while maintaining homogeneous cellular distribution, which will be reported in the due course

Sixteen of these cell lines were sensitive to CB-839 treatment and had an antiproliferative IC 50 of less than 100 nM (range, 2-72 nM)

This range derives from scaling the effective doses in rat studies (approximately 10 micrograms per kilogram of body weight) to human physiology using established interspecies conversion factors