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Under normal physiological conditions, when cellular redox levels are stable, Nrf2 is sequestered in the cytoplasm by Keap1, which binds to Nrf2 through the cullin3 (Cul3) ubiquitin ligase-containing E3 complex [17]

Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1beta-induced fibroblast-like synoviocytes through regulating the activation of NF-B and JAK/STAT-signaling pathways

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doi: 10.1016/j.cmet.2019.11.010 50 KaganJC