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Subsequently, single-cell sequencing data, were preprocessed with StanDep 20 to identify core sets of reactions active in each cell which then were used to identify context-specific metabolic networks that contain those reactions using fastcore 21

Disturbed cell fate regulation: apoptosis, autophagy and epigenetic alterations During ovarian aging, mitochondrial dysfunction, ROS accumulation and mtDNA damage significantly activate the endogenous apoptotic pathway, as evidenced by an elevated Bax/Bcl-2 ratio, activation of caspase-3/9 and Cyt c leakage [334]

doi: 10.1021/acsnano.3c04887 132 FontanaFFuscielloMGroeneveldtCCapassoCChiaroJFeolaSet al

The associations of circulating common and uncommon polyunsaturated fatty acids and modification effects on dietary quality with all-cause and disease-specific mortality in NHANES 2003-2004 and 2011-2012