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Abbreviations AT: Achilles tendinopathy Col1A1: collagen type I alpha-1 CTGF: connective tissue growth factor DS: diclofenac sodium ECM: extracellular matrix HC: healthy control H&E: hematoxylin-eosin IHC: immunohistochemical MTC: Massons trichrome NSAID: nonsteroidal anti-inflammatory drug PBS: phosphatic buffer solution OS: oxidative stress OSI: oxidative stress index ROS: reactive oxygen species SMAD: mothers against decapentaplegic TAS: total antioxidant status TGF-: transforming growth factor-beta TOS: total oxidant status WH: wound healing References Lantto I, Heikkinen J, Flinkkil T et al (2015) Epidemiology of Achilles tendon ruptures: increasing incidence over a 33-year period