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129,130 By promoting the expression of RBM3, sodium butyrate indirectly inhibits the expression of SLC7A11, 131 thus aggravating ferroptosis of endometrial cancer cells and inhibiting cell clonal formation and cell proliferation

Loss of PTEN removes the control that limits the PI3K/AKT pathway that regulates cell growth, and this allows glands in the endometrium to show dense arrangement and nuclear features indicating atypia under continued stimulation by estrogen (99)