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The following medications have already shown their effectiveness as a targeted treatments: Inhibitors Targeting Protein Kinase B (Akt)/Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Pathway Cyclin-Dependent Kinases 4 and 6 Inhibitors (CDK 4/6 Inhibitors) Poly (ADP ribose) Polymerase (PARP) Inhibitors Tyrosine Kinase Inhibitors Vascular Endothelial Growth Factor-A Inhibitors The current multimodal approach employed for breast cancer treatment has undoubtedly improved the overall survival of patients and has greatly improved their quality of life [53]

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In patients unfortunate enough to have suffered multiple episodes, these abnormalities intensify, resulting in higher overall cortisol levels in addition to aberrant reactivity, and even greater flattening of their cortisol curves, compared with patients who have experienced only a few episodes (173)

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