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Alpha-smooth muscle actin expression upregulates fibroblast contractile activity

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Afamelanotide is the International Nonproprietary Name.[4] History The role of -MSH in promoting melanin diffusion has been known since the 1960s.[5] In the 1980s, scientists at University of Arizona began attempting to develop -MSH and analogs as potential sunless tanning agents, and synthesized and tested several analogs, including melanotan-I.[6] To pursue the tanning agent, melanotan-I was licensed by Competitive Technologies, a technology transfer company operating on behalf of University of Arizona, to an Australian startup called Epitan,[7][6] which changed its name to Clinuvel in 2006.[8] Early clinical trials showed that the peptide had to be injected about ten times a day due to its short half-life, so the company collaborated with Southern Research in the US to develop a depot formulation that would be injected under the skin, and release the peptide slowly