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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss

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Recent clinical and preclinical studies have demonstrated that metformin not only ameliorates insulin sensitivity, but also facilitates glucose-lipid reverse transport, alleviates hormone imbalances induced by glucose metabolic irregularities, and ameliorates symptoms associated with hormonal dysregulation in patients with PCOS (Shen et al., 2022

Interest in such applications is largely driven by their proposed mechanisms of action, including enhancement of tissue repair, modulation of inflammation, and cytoprotective effects observed in preclinical studies