It has been observed that normal skin melanocytes produce significant levels of the anti-apoptotic protein BCL2, which plays a crucial role in promoting melanocyte survival [211,212]
Funding This research was funded by Zhejiang Province Medical and Health Technology Plan Project, China (2024KY219), Zhejiang Traditional Medicine and Technology Program, China (2024ZR114), Hangzhou Municipal Health Commission Project, China (A20231278), National Science Foundation of China (82505280) and the Construction fund of Key medical Disciplines of Hangzhou under Grand, China (2025HZGF12, 2025HZPY05)
For instance, the efficacy of metformin may vary among different patients with PCOS
Mechanism: Regulates the endocrine and immune functions by interacting with the thymus gland, critical for T-cell maturation and immune response fine-tuning