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We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)

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Plasma ChE activities returned to normal within approximately 3 weeks, whereas the erythrocyte ChE activities required 50 - 60 days to return to pre- treatment values (Hass et al., 1972)