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23 In the whole study, we used control littermates IR flox/flox mice as controls

doi: 10.1371/journal.pgen.1003083 165 HuangX.YiY.YongJ.SunJ.SongZ.LiD.et al

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Addition of a methyl group (-CH3) to the 3 position changes morphine to codeine, masks the OH group and confers greater fat-solubility to the molecule allowing it to be more preferentially absorbed