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Histological analyses Murine cardiac tissue samples were isolated, fixed for 48 h with 4% paraformaldehyde, paraffin-embedded, and cut into 5 mm cross-sections that were stained with hematoxylin and eosin (H&E) to assess histopathological changes

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The duration of tranexamic acid therapy should not be shortened due to the high risk of melasma relapse after discontinuation (Kim et al., 2017)

To determine the effect of RhoA on OA in vivo, OA progression in mice 8 weeks post-DMM was assessed using H&E, safranin-O-fast green and Masson staining