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In OA studies, direct intra-articular injection of Fer-1 into mouse or rat models significantly reduced the accumulation of lipid peroxidation end-products like MDA and 4-HNE in cartilage tissue, alleviated the degree of ECM degradation, and improved overall joint pathology scores

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First , sermorelin is not FDA-approved for metabolic or weight management indications, and its use in these contexts remains off-label with limited evidence quality