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Significantly, a major challenge currently lies in the selective targeting of lactylation without affecting other PTMs, as they are intricately linked and share a common set of regulatory enzymes, such as p300, HDACs, and Sirts, complicating the specific inhibition of lactylation

Semaglutide compared with liraglutide and placebo for weight loss in obesity

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Wegovy helps regulate appetite and promotes weight loss, while Ozempic stimulates insulin release after meals, lowers blood sugar, and slows stomach emptying