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Using this model, we now demonstrate that Trkb deletion-induced iSPN dysfunction leads to a hyperdopaminergic state in the pre-symptomatic phase, before motor dysfunction onset, reminiscent of the dopaminergic dysfunction observed in the brains of patients with HD 3,4,5

While this isnt harmful for most people, individuals with kidney issues or impaired detoxification pathways may struggle to process it effectively

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The procedure is typically offered to individuals with a body mass index (BMI) of 40 kg/m or above, or 35 kg/m and above with obesity-related health conditions such as type 2 diabetes or hypertension, in line with NICE guidance (CG189)