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3 Glucocorticoid-induced myopathy and skin atrophy 3.1 Pathogenesis GCs induce catabolic/atrophic changes in multiple tissues including muscle, subcutaneous fat, and bone [52, 53]

2016;43(suppl):S96109

A study involving wild-type (WT) and p53 knockout (p53 -/-) mouse embryonic fibroblasts (MEFs) demonstrated that pretreatment with 10 mol/L of selenomethionine (SLM) for 15 hours, followed by exposure to cisplatin or oxaliplatin, revealed a protective effect of selenium on WT-MEFs