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Cancers (Basel) 12(2):310 Okazaki A, Gameiro PA, Christodoulou D (2017) Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

Consistent with this, depleting mouse skeletal muscle NAD + levels by 85% did not affect muscle function, muscle aging, or organismal aging ( Lastly, although redox coenzyme ratios change with aging in mouse brain, they remained unaltered with aging in mouse liver