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650 nm filter) using or excluding a gel of kojic acid, a transethosome encapsulating ferrous chlorophyllin (Fe-CHL), a lipid-based NP, caused a progressive reduction in the size of the tumor in a melanoma mouse model, which totally regressed under one month [268]

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Thats my take on this paper

The etiology primarily lies beside the abnormal skin cell proliferation facilitated by the unrepaired DNA of skin cells which owes to DNA mutations or genetic defects