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Through the estrogen binding to its receptor, tyrosinase and microphthalmia transcription factor (MITF) can be activated and therefore melanin would be increased (Lee, 2015)

This also means the participation of multiple disciplines, including the department of sexual medicine, urology, nutrition, cardiology, and endocrinology, to provide effective and comprehensive guidance for personalized management

Introduction The functions of proteins are closely associated with their subcellular localization and protein interactions ( via post-translational modifications (PTMs), which have varied impacts on the targeted proteins (Su et al., 2021

& Gillies, R