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Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo

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Depending on the combination of the different chemical groups and which AA residue they are attached to, chromatin will assume distinct physical states (Jenuwein and Allis, 2001)

35,36 They can carry various cargo, including microRNAs (miRNAs), short noncoding RNA, proteins, DNA, messenger RNA (mRNA), nucleic acids and lipids