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As an analog of endogenous growth hormone-releasing hormone (GHRH), tesamorelin boasts a metabolism-stimulating activity that has led to its being approved as a treatment for lipodystrophy, or abnormal adipose fat accumulation associated with antiretroviral therapy for HIV.3 But this same activity can help non-HIV individuals shed abdominal fat of their own, while the peptides GHRH properties make it a suitable therapy for people looking to increase their lean mass

There is a corelation between tonicity agent and observed subcutaneous necrosis at the injection site

That is a large subcutaneous injection

1993 Nov;92(5):2368-2376