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Information sources and search strategy Two independent reviewers searched PubMed, Web of Science, and Scopus databases, covering the period from January 1980 to March 2025

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Phase 3 Standard Cagrilintide Dose Based on Phase 2 findings, the standard cagrilintide dose for Phase 3 trials was established at: 2.4 mg administered subcutaneously once weekly This dose represents the optimal balance between: Efficacy : Substantial weight loss and metabolic improvements Safety : Manageable side effect profile Tolerability : Acceptable patient adherence rates The REDEFINE 1 trial, which evaluated cagrilintide in combination with semaglutide (CagriSema), used this 2.4 mg dose and demonstrated remarkable results

BPC-157 is not an approved medicine