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Study Design and Population Researchers investigated whether early smoking initiation independently increases mortality and cardiovascular risks and whether it modifies the effects of cumulative smoking exposure

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Discussion Due to the increased worldwide popularity of HTPs like IQOS and their marketing as a safer alternative to combustible cigarettes owing to industry-generated safety data, we assessed for the first time whether switching from chronic cigarettes to HTPs can indeed reverse or minimize immunocompromising effects of cigarette smoke inhalation