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Public RNA-seq datasets, including TCGA-LIHC, OEP000321, and ICGC-LIRI-JP, were retrieved from The Cancer Genome Atlas ( the NODE database ( and the International Cancer Genome Consortium ( respectively

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[9] Using retatrutide outside of an approved, ethics-committee-reviewed clinical trial carries significant risks, as research-grade peptides are not subject to the same manufacturing standards, purity controls, or safety oversight as licensed medicines

Two decades later, Kovalzon and Strekalova (2006) [6] were equally direct, calling DSIP a still unresolved riddle and noting that the connection between the peptide and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. That framing has not materially changed in the literature since