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When follicles are miniaturizing but not yet dead, peptides can reverse the trend and restore healthy function

Female guinea pigs (Charles River) weighing 200-300 g, of approximately 6-8 weeks of age are used (N=4 per group)

The combination limited and variable BBB transport plus rapid plasma degradation means peripherally administered DSIP delivers a brief and structurally heterogeneous exposure to the central nervous system, complicating dose-response interpretation in any whole-animal experiment

Otherwise, if increased angiogenesis appears as dysregulation, as a likely possibility, regardless of beneficial effects, there is a considerable probability that increased angiogenesis precedes the complications and impedes uncontrolled VEGF, the egr-1 gene, carcinoma, and the NO-system [1]