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Some users employ a combination approach

In summary, while structurally similar dimethylxanthines have different physiological effects, the impact of theophylline and theobromine on cognition is generally less pronounced than that of caffeine and paraxanthine

These overall immunological responses contribute to the enlargement and overgrowth of the synovial lining, destruction of cartilage, formation of osteoclasts, synovial inflammation, pain, and an elevated risk of neoplastic infections [12]

doi: 10.3389/fphar.2014.00168 Received 11 May 2014 Accepted 25 June 2014 Published 17 July 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Jose A