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The insights gained from this review will contribute to the development of novel therapeutic approaches aimed at tipping the balance in favor of the immune system and improving patient outcomes

doi: 10.1038/s41593-019-0532-y 294 SantosE

found that CD8 + T cells hardly express asparagine synthase (ASNS) during the early stage of CD8 + T cell activation and that the growth, activation, and metabolic reprogramming of CD8 + T cells are disrupted in the context of Asn deprivation