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In mice, GPX4 knockdown leads to age-dependent neurodegenerative changes and neuronal loss, which can be exacerbated by dietary deficiency of vitamin E (a ferroptosis inhibitor) 61

Clinical studies show a variety of potential applications, such as quicker wound healing and anti-inflammatory benefits

Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W