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Confirming normal organ function is required prior to safely initiating disease-modifying antirheumatic drugs (DMARDs) like methotrexate (Cohen & Mikuls, 2025

These early adaptations probably contribute to the systemic metabolic remodelling observed in Taz -KD mice, including elevated FGF-21 levels and increased glucose uptake across multiple tissues

doi: 10.1016/j.fpsl.2017.09.001 71

3 Microbial metabolites in SZ pathology: BBB disruption and neuroinflammation The alterations in microbial composition described above are closely linked to functional disturbances in the gut ecosystem of patients with schizophrenia