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Beyond its well-established local anti-inflammatory actions, emerging evidence suggests that 5-ASA contributes to mucosal immune homeostasis through immunometabolic regulationnot as a T cellspecific drug, but via broader mechanisms including activation of the AhRIDO1 axis (256)

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However, well-designed DSHP/DSIP programs have demonstrated impressive returns on investment through reduced hospitalizations, decreased emergency department usage, and lower long-term care costs

Nicotinamide (a form of vitamin B3), also known as niacinamide, is needed for numerous metabolic reactions in the body and has been used historically to treat rosacea