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Interestingly, Phase lll detoxification can often be considered a rate-limiting factor in detoxification due to the fact that intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the bodys natural detoxification pathways

The gastrointestinal-protection profile motivated the Pliva clinical development program (PL-10, PLD-116, PL 14736) for inflammatory bowel disease

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This signal is the cornerstone of the hypothalamic-pituitary-gonadal (HPG) axis: it triggers the pulsatile release of GnRH, which in turn stimulates the secretion of LH and FSH by the pituitary gland