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At L5-S1, the S1 nerve root compression follows a different path, running from the lower back or buttock down the back of the thigh into the calf and heel

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However, evidence from research studies suggests that GLP-1 analogs may also reduce gastric acid secretion, which can impair the conversion of dietary B12 into its absorbable form and decrease binding to intrinsic factor, both of which are necessary for proper absorption