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Therefore, oral B12 supplements can be taken with or without food with minimal impact on absorption

10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

This method is often used to treat or prevent vitamin B12 deficiency, which can lead to serious health problems if left untreated

Further into the study, researchers utilized Western blotting, a laboratory method to detect specific proteins in a sample