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Selenium: A vital mineral that supports glutathione activity and immune function

Toxicol Rep 8:395404 Muhammad N, Ur Rahman S, Uddin H, Shehzad O, Ismail M, Ali N, Khan A, Shahid M, Ullah A, Ahmad S, Hussain H (2022) Antidiarrheal and antispasmodic activities of Trillium govanianum rhizomes extract: involvement of calcium channel blockade

For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

doi: 10.1152/jappl.1993.75.6.2419