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Astaxanthin has been shown to increase BDNF levels studies in rodents and human cells (in vitro) Improvements in memory are observed in some studies but with variability across demographics These neurocognitive benefits may be through reduced lipid peroxidation Longevity pathways: Astaxanthin mechanistically modulates key longevity genes, including FOXO3, Sirt1, Klotho, and Nrf2
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For instance, a study demonstrated that blocking MCU significantly reduced ROS production and mitochondrial swelling in iron-overloaded thalassemic mice, suggesting that MCU could be a therapeutic target for preventing mitochondrial dysfunction in IOC (41, 89)