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Its activation may be advantageous in early disease, whereas in advanced pancreatitis marked by lysosomal insufficiency and impaired mitochondrial replenishment, continued sequestration of mitochondria into incompletely resolved autophagic vacuoles could theoretically aggravate bioenergetic decline

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Acknowledgements We thank Colleen McHugh and Harriet Pratley for the generation of GspD/PilQ antisera, Jos Muoz-Dorado for providing plasmids for copper-inducible gene expression, Tm Mignot, Emilia Mauriello, and Penelope Higgs for providing carbohydrate deletion strains, Daniel Bollschweiler, Florian Beck, and Harald Engelhardt (MPI of Biochemistry, Martinsried) for their help with averaging the negatively stained A