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Gastrointestinal safety of semaglutide and tirzepatide vs placebo in obese individuals without diabetes: a systematic review and meta-analysis

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Final effect (day 10): On day 10, the blood-deprived colon segment contained extremely large pale areas without mucosal folds that occupied the entire area between the ligations (Table 3, Figure 20)

While short-term preclinical studies suggest favorable safety, chronic administration effects on angiogenesis, growth factor signaling, and tissue remodeling over years of use remain unknown