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A 2019 study assessed data from a nationwide survey of nearly 450,000 participants and found no significant association between e-cigarette use and heart disease

One speculative, possible explanation would be that the detrimental effects of maternal smoking on congenital anomalies mainly originate from an earlier period in pregnancy: morphogenesis is influenced mainly during the first days of embryogenesis, whereas later days of pregnancy involve mostly about growth of the embryo

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