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The regulatory effect of metformin on the microbiota extends beyond GSH to include microbial metabolites such as short-chain fatty acids (SCFAs), which have been shown to inhibit tumor proliferation and protect against intestinal injury [34,35,36]

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Anecdotal/observational reports (body composition, energy, recovery) exist in performance settings, but lack standardized dosing, controls, and validated endpoints

It stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it only triggers insulin when blood sugar is elevated