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TRPV1 is also activated by capsaicin (hot peppers), low extracellular pH, and noxious heat.[ref] TRPA1 is activated by VOCs, cigarette smoke, heavy metals, naphthalene (moth balls), formaldehyde, and styrene.[ref] TRP receptors are highly expressed in the olfactory and trigeminal nerve endings and in the brain

Glutathione Glutathione, often referred to as the master antioxidant, is a tripeptide consisting of three amino acids: cysteine, glutamate, and glycine

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In sick dogs, oxidative stress has been highlighted as a concern, and antioxidant supplementation may be used as supportive care under veterinary guidance